This resource, developed by the National Institute for Health Research (NIHR) Research Design Service North West (RDS NW), aims to help you ensure an application for funding for a trial includes key considerations at each stage e.g. trial design, costs, conduct, reporting and analysis. This resource brings together a number of externally hosted resources.
The focus is to support clinical trials but many aspects of the guidance are common to other research studies.
Details of support available, when applying and carrying out a trial in the North West of England are provided. This includes information about:
Here you will also find information and details on sources appropriate to pre-funding, including:
RDS NW and CTUs are funded by the NIHR. Both have a shared goal of improving the quality of applications submitted. To ensure a consistent approach pre and post funding for the design and analysis investigators are encouraged to have a joint discussion with CTUs and the RDS NW. This should be arranged as early as possible.
The links and information in this resource are split into four sections, each accessible using the button links at the top of the page or the first drop-down menu if viewing on a small screen. The first three sections focus on areas relating to producing a trial funding application. The fourth section provides details on how to find clinical expects to help with all aspects of your trial funding application.
Each of these sections are further split into various topics which are listed in the menu on the left of the screen or in the second drop-down menu on a small screen. Use this menu to access the various links and information under each sub-section.
Please note RDS NW is not responsible for any externally hosted resources.
Support in designing a clinical trial should be sought as early as possible and is available from the National Institute for Health Research (NIHR) Research Design Service North West (RDS NW) and/or the Clincal Trials Units (CTU). CTUs are funded to support the pre-funding development of trials. RDS offer advice on the design of the trial and other complimentary aspects including:
Applications for research funding should consider the design of the methods and the conduct to ensure adequate resources are costed and achievable within the grant. CTUs and RDS NW work collaboratively with investigators to ensure all aspects are included in the application.
RDS advisers may also refer you to the Medical Research Council (MRC) Hub's Methodology Advisory Service for Trials (MAST) for non-standard methodology to access more specialised guidance from methodologists throughout the UK.
There are many resource that you can use to help you design a trial and related funding application. Use the options in this section to access useful links and resource for particular aspects of trial design.
Costing a proposal involving a trial can be a complex and time consuming process. For large and complex trials, this can take up to six weeks, often involving:
These should be contacted as early as possible where appropriate.
This section covers links to funding that is appropriate for studies involving trials or feasibility.
It also includes links to key reference documents for costing NIHR studies as well as links to resources that provide advice on appropriate funding.
Support within the NIHR infrastructure includes:
Use the links in this sections to find out more on CTUs and those in the North West of England. You will also find links in this section providing information on the Clinical Research Network as well as useful resources on trial management.
NIHR funders encourage investigators to involve either the Clinical Studies Groups or the Speciality Research Groups.
The NIHR has a framework of support for 30 specialities grouped within six divisions. Each speciality and division has a lead. For multicentre studies the lead will liaise with other sites on your behalf to support the research.
Use the links in this sections to find out more on the CRN specialities.